InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MOGAT3

Summary

InnateDB Protein

IDBP-33099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MOGAT3

Protein Name

monoacylglycerol O-acyltransferase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000223114

InnateDB Gene

IDBG-33097 (MOGAT3)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. {ECO:0000269PubMed:12618427}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Selectively expressed in the digestive system. Highly expressed in the ileum, and at lower level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and trachea. Expressed at very low level in liver. {ECO:0000269PubMed:12618427}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003846	2-acylglycerol O-acyltransferase activity
GO:0004144	diacylglycerol O-acyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups