InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SREBF1

Summary

InnateDB Protein

IDBP-33212.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SREBF1

Protein Name

sterol regulatory element binding transcription factor 1

Synonyms

bHLHd1; SREBP-1c; SREBP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000348069

InnateDB Gene

IDBG-33208 (SREBF1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.Processed sterol regulatory element-binding protein 1: Nucleus.Isoform SREBP-1aDelta: Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:18267114}.Isoform SREBP-1cDelta: Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:18267114}.

Disease Associations

Tissue Specificity

Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	101 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0032810	sterol response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003062	regulation of heart rate by chemical signal
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0008203	cholesterol metabolic process
GO:0008286	insulin receptor signaling pathway
GO:0008610	lipid biosynthetic process
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0019217	regulation of fatty acid metabolic process
GO:0030324	lung development
GO:0031065	positive regulation of histone deacetylation
GO:0032094	response to food
GO:0032526	response to retinoic acid
GO:0032570	response to progesterone
GO:0032869	cellular response to insulin stimulus
GO:0033762	response to glucagon
GO:0033993	response to lipid
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046676	negative regulation of insulin secretion
GO:0050796	regulation of insulin secretion
GO:0051591	response to cAMP
GO:0070542	response to fatty acid
GO:0071398	cellular response to fatty acid

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex