InnateDB Protein
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IDBP-33214.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SREBF1
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Protein Name
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sterol regulatory element binding transcription factor 1
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Synonyms
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bHLHd1; SREBP-1c; SREBP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261646
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InnateDB Gene
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IDBG-33208 (SREBF1)
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Protein Structure
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Function |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.Processed sterol regulatory element-binding protein 1: Nucleus.Isoform SREBP-1aDelta: Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:18267114}.Isoform SREBP-1cDelta: Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:18267114}.
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Disease Associations |
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Tissue Specificity |
Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
109
[view]
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Protein-Protein |
101
[view]
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Protein-DNA |
7
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006629
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lipid metabolic process
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GO:0008610
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lipid biosynthetic process
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GO:0009267
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cellular response to starvation
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GO:0010867
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positive regulation of triglyceride biosynthetic process
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
P36956
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PhosphoSite |
PhosphoSite-P36956
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TrEMBL |
J3QLB6
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UniProt Splice Variant |
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Entrez Gene |
6720
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UniGene |
Hs.592123
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RefSeq |
NP_004167
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HUGO |
HGNC:11289
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OMIM |
184756
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CCDS |
CCDS11189
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HPRD |
01701
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IMGT |
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EMBL |
AB209609
AB373958
AB373959
AC122129
BC023621
BC026962
BC057388
BC063281
CH471196
S66167
S66168
U00968
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GenPept |
AAB28522
AAB28523
AAC50051
AAH23621
AAH26962
AAH57388
AAH63281
BAD92846
BAG06742
BAG06743
EAW55689
EAW55690
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