InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE3B

Summary

InnateDB Protein

IDBP-33217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE3B

Protein Name

phosphodiesterase 3B, cGMP-inhibited

Synonyms

cGIPDE1; HcGIP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000282096

InnateDB Gene

IDBG-33215 (PDE3B)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269PubMed:15147193, ECO:0000269PubMed:21393242}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Abundant in adipose tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004119	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0043422	protein kinase B binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006198	cAMP catabolic process
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0031018	endocrine pancreas development
GO:0032869	cellular response to insulin stimulus
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0042593	glucose homeostasis
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0050796	regulation of insulin secretion
GO:0050995	negative regulation of lipid catabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032045	guanyl-nucleotide exchange factor complex