InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE3B

Summary

InnateDB Gene

IDBG-33215.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE3B

Gene Name

phosphodiesterase 3B, cGMP-inhibited

Synonyms

cGIPDE1; HcGIP1

Species

Homo sapiens

Ensembl Gene

ENSG00000152270

Encoded Proteins

IDBP-33217

phosphodiesterase 3B, cGMP-inhibited

IDBP-367411

phosphodiesterase 3B, cGMP-inhibited

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:14643723-14872044

Strand

Forward strand

Band

p15.2

Transcripts

ENST00000282096	ENSP00000282096
ENST00000455098	ENSP00000388644
ENST00000534317
ENST00000532740
ENST00000525439

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004119	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0043422	protein kinase B binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006198	cAMP catabolic process
GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0016525	negative regulation of angiogenesis
GO:0031018	endocrine pancreas development
GO:0032869	cellular response to insulin stimulus
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0042593	glucose homeostasis
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0050796	regulation of insulin secretion
GO:0050995	negative regulation of lipid catabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032045	guanyl-nucleotide exchange factor complex