InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOV

Summary

InnateDB Protein

IDBP-33779.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOV

Protein Name

nephroblastoma overexpressed gene

Synonyms

CCN3; IBP-9; IGFBP-9; IGFBP9; NOVh;

Species

Homo sapiens

Ensembl Protein

ENSP00000259526

InnateDB Gene

IDBG-33777 (NOV)

Protein Structure

UniProt Annotation

Function

Immediate-early protein likely to play a role in cell growth regulation. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type. {ECO:0000269PubMed:1756408}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008083	growth factor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0010468	regulation of gene expression

Cellular Component

GO:0005576	extracellular region
GO:0030424	axon
GO:0030425	dendrite
GO:0031012	extracellular matrix
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR000884 Thrombospondin, type 1 repeat
IPR001007 von Willebrand factor, type C
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR012395 IGFBP-related, CNN

PFAM

PF00219
PF00090
PF00093
PF00007

PRINTS

PIRSF

PIRSF036495

SMART

SM00121
SM00209
SM00214
SM00041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt