Homo sapiens Protein: KPNA3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-33880.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | KPNA3 | ||||||||||||||||||||||
Protein Name | karyopherin alpha 3 (importin alpha 4) | ||||||||||||||||||||||
Synonyms | hSRP1; IPOA4; SRP1; SRP1gamma; SRP4; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000261667 | ||||||||||||||||||||||
InnateDB Gene | IDBG-33878 (KPNA3) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000225
Armadillo IPR000357 HEAT IPR002652 Importin-alpha, importin-beta-binding domain IPR016024 Armadillo-type fold |
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PFAM |
PF00514
PF02985 PF01749 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00185
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O00505 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O00505 | ||||||||||||||||||||||
TrEMBL | A0A024RDV7 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 3839 | ||||||||||||||||||||||
UniGene | Hs.733349 | ||||||||||||||||||||||
RefSeq | NP_002258 | ||||||||||||||||||||||
HUGO | HGNC:6396 | ||||||||||||||||||||||
OMIM | 601892 | ||||||||||||||||||||||
CCDS | CCDS9421 | ||||||||||||||||||||||
HPRD | 03536 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF005263 AF034756 AK290528 AK291000 AL135901 AL136301 BC017355 BC024202 CH471075 D89618 Y12394 | ||||||||||||||||||||||
GenPept | AAB87693 AAH17355 AAH24202 AAQ13404 BAA20378 BAF83217 BAF83689 CAA73026 CAH71145 CAI40716 EAX08837 EAX08839 | ||||||||||||||||||||||