InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XBP1

Summary

InnateDB Protein

IDBP-3434.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XBP1

Protein Name

X-box binding protein 1

Synonyms

TREB5; XBP-1; XBP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000216037

InnateDB Gene

IDBG-3430 (XBP1)

Protein Structure

UniProt Annotation

Function

Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax- responsive element (TRE) of HTLV-I. {ECO:0000269PubMed:11779464, ECO:0000269PubMed:2196176, ECO:0000269PubMed:2321018, ECO:0000269PubMed:8349596, ECO:0000269PubMed:8657566}.

Subcellular Localization

Nucleus.

Disease Associations

Major affective disorder 7 (MAFD7) [MIM:612371]: A major psychiatric disorder that is characterized by severe mood swings, with fluctuation between two abnormal mood states (manic or major depressive episode). Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	28 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085	RNA polymerase II transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002070	epithelial cell maturation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031017	exocrine pancreas development
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051602	response to electrical stimulus
GO:0060096	serotonin secretion, neurotransmission
GO:0060691	epithelial cell maturation involved in salivary gland development
GO:0071236	cellular response to antibiotic
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
GO:1901800	positive regulation of proteasomal protein catabolic process