InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: XBP1

Summary

InnateDB Gene

IDBG-3430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XBP1

Gene Name

X-box binding protein 1

Synonyms

TREB5; XBP-1; XBP2

Species

Homo sapiens

Ensembl Gene

ENSG00000100219

Encoded Proteins

IDBP-3432

X-box binding protein 1

IDBP-3434

X-box binding protein 1

IDBP-294778

X-box binding protein 1

IDBP-294775

X-box binding protein 1

IDBP-810578

X-box binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20351694

XBP1 transcription factor regulates innate immune responses in macrophages via TLR2 activation and its deficiency results in a much greater bacterial burden in mice infected with the TLR2-activating human intracellular pathogen Francisella tularensis.

PMID 20533428

XBP1/ERN1 (IRE1)-mediated signalling plays roles in the coordination of metabolic and immune responses by acting as a regulatory hub, linking endoplasmic reticulum homeostasis with innate immunity and metabolism.

PMID 20660350

XBP1 interacts with EP300 to augment IFN-beta induction via a cis-acting enhancer in macrophages under endoplasmic reticulum stress.

PMID 21400498

XBP1 is an important regulator in ER stress response and may function collaboratively with innate immunity to maintain cellular homeostasis. XBP1 is essential in poly(I:C)-signalling and ER stress-amplified IFNB production in dendritic cells, and the over-expression of XBP1 synergistically augments the poly(I:C)-induced inflammatory response. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 20351694

[Mus musculus] Xbp1 transcription factor regulates innate immune responses in macrophages via Tlr2 activation and its deficiency results in a much greater bacterial burden in mice infected with the Tlr2-activating human intracellular pathogen Francisella tularensis.

PMID 21400498

[Mus musculus] Xbp1 is an important regulator in ER stress response and may function collaboratively with innate immunity to maintain cellular homeostasis. Xbp1 is essential in poly(I:C)-signalling and ER stress-amplified IFNB production in dendritic cells, and the over-expression of Xbp1 synergistically augments the poly(I:C)-induced inflammatory response.

Entrez Gene

Summary

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:28794555-28800597

Strand

Reverse strand

Band

q12.1

Transcripts

ENST00000344347	ENSP00000343155
ENST00000216037	ENSP00000216037
ENST00000403532	ENSP00000385162
ENST00000405219	ENSP00000384295
ENST00000484256
ENST00000482720
ENST00000611155	ENSP00000481170

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	28 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085	RNA polymerase II transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002070	epithelial cell maturation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031017	exocrine pancreas development
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051602	response to electrical stimulus
GO:0060096	serotonin secretion, neurotransmission
GO:0060691	epithelial cell maturation involved in salivary gland development
GO:0071236	cellular response to antibiotic
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
GO:1901800	positive regulation of proteasomal protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020484

View Gene Order

ENSBTAG00000005970

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

hnf3apathway

FOXA1 transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001079539 NM_005080

HUGO

OMIM

CCDS

CCDS13847

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas