Homo sapiens Gene: XBP1
Summary
InnateDB Gene IDBG-3430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XBP1
Gene Name X-box binding protein 1
Synonyms TREB5; XBP-1; XBP2;
Species Homo sapiens
Ensembl Gene ENSG00000100219
Encoded Proteins
X-box binding protein 1
X-box binding protein 1
X-box binding protein 1
X-box binding protein 1
X-box binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
XBP1 transcription factor regulates innate immune responses in macrophages via TLR2 activation and its deficiency results in a much greater bacterial burden in mice infected with the TLR2-activating human intracellular pathogen Francisella tularensis.
XBP1/ERN1 (IRE1)-mediated signalling plays roles in the coordination of metabolic and immune responses by acting as a regulatory hub, linking endoplasmic reticulum homeostasis with innate immunity and metabolism.
XBP1 interacts with EP300 to augment IFN-beta induction via a cis-acting enhancer in macrophages under endoplasmic reticulum stress.
XBP1 is an important regulator in ER stress response and may function collaboratively with innate immunity to maintain cellular homeostasis. XBP1 is essential in poly(I:C)-signalling and ER stress-amplified IFNB production in dendritic cells, and the over-expression of XBP1 synergistically augments the poly(I:C)-induced inflammatory response. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Xbp1 transcription factor regulates innate immune responses in macrophages via Tlr2 activation and its deficiency results in a much greater bacterial burden in mice infected with the Tlr2-activating human intracellular pathogen Francisella tularensis.
[Mus musculus] Xbp1 is an important regulator in ER stress response and may function collaboratively with innate immunity to maintain cellular homeostasis. Xbp1 is essential in poly(I:C)-signalling and ER stress-amplified IFNB production in dendritic cells, and the over-expression of Xbp1 synergistically augments the poly(I:C)-induced inflammatory response.
Entrez Gene
Summary This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:28794555-28800597
Strand Reverse strand
Band q12.1
Transcripts
ENST00000344347 ENSP00000343155
ENST00000216037 ENSP00000216037
ENST00000403532 ENSP00000385162
ENST00000405219 ENSP00000384295
ENST00000484256
ENST00000482720
ENST00000611155 ENSP00000481170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 28 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085 RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002070 epithelial cell maturation
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031017 exocrine pancreas development
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051602 response to electrical stimulus
GO:0060096 serotonin secretion, neurotransmission
GO:0060691 epithelial cell maturation involved in salivary gland development
GO:0071236 cellular response to antibiotic
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL B1AHH2
UniProt Splice Variant
Entrez Gene 7494
UniGene Hs.437638
RefSeq NM_005080 NM_001079539
HUGO HGNC:12801
OMIM 194355
CCDS CCDS13847
HPRD 01908
IMGT
EMBL Z93930
GenPept
RNA Seq Atlas 7494