InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPH1

Summary

InnateDB Protein

IDBP-34422.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPH1

Protein Name

tryptophan hydroxylase 1

Synonyms

TPRH; TRPH;

Species

Homo sapiens

Ensembl Protein

ENSP00000250018

InnateDB Gene

IDBG-34418 (TPH1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 2 seems to be less widely expressed than isoform 1.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004510	tryptophan 5-monooxygenase activity
GO:0005506	iron ion binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0007623	circadian rhythm
GO:0008152	metabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0030279	negative regulation of ossification
GO:0034641	cellular nitrogen compound metabolic process
GO:0035902	response to immobilization stress
GO:0042427	serotonin biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046219	indolalkylamine biosynthetic process
GO:0046849	bone remodeling
GO:0055114	oxidation-reduction process
GO:0060749	mammary gland alveolus development

Cellular Component

GO:0005829	cytosol
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR002912 ACT domain
IPR005963 Tryptophan 5-monooxygenase
IPR019773 Tyrosine 3-monooxygenase-like
IPR019774 Aromatic amino acid hydroxylase, C-terminal

PFAM

PF01842
PF00351

PRINTS

PR00372

PIRSF

PIRSF000336

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt