InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TPH1

Summary

InnateDB Gene

IDBG-34418.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPH1

Gene Name

tryptophan hydroxylase 1

Synonyms

TPRH; TRPH

Species

Homo sapiens

Ensembl Gene

ENSG00000129167

Encoded Proteins

IDBP-34422

tryptophan hydroxylase 1

IDBP-368232

tryptophan hydroxylase 1

IDBP-592346

tryptophan hydroxylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23243271

[Mus musculus] Tph1-deficient mice lack non-neuronal serotonin, and show impairment in neutrophil recruitment to sites of acute inflammation.

Entrez Gene

Summary

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:18017564-18042426

Strand

Reverse strand

Band

p15.1

Transcripts

ENST00000250018	ENSP00000250018
ENST00000417164	ENSP00000403831
ENST00000525406
ENST00000528338	ENSP00000436081

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004510	tryptophan 5-monooxygenase activity
GO:0005506	iron ion binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0007623	circadian rhythm
GO:0008152	metabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0030279	negative regulation of ossification
GO:0034641	cellular nitrogen compound metabolic process
GO:0035902	response to immobilization stress
GO:0042427	serotonin biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046219	indolalkylamine biosynthetic process
GO:0046849	bone remodeling
GO:0055114	oxidation-reduction process
GO:0060749	mammary gland alveolus development

Cellular Component

GO:0005829	cytosol
GO:0043005	neuron projection

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040046

View Gene Order

ENSBTAG00000005343

Not yet available

Pathways

NETPATH

REACTOME

REACT_15439

Serotonin and melatonin biosynthesis pathway

REACT_15513

Amine-derived hormones pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.349122 Hs.591999 Hs.602529 Hs.613954 Hs.668317

RefSeq

NM_004179

HUGO

OMIM

CCDS

CCDS7829

HPRD

01846

IMGT

EMBL

GenPept

RNA Seq Atlas