Version 5.4
Homo sapiens Protein: TIFA
Summary
InnateDB Protein IDBP-34440.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIFA
Protein Name TRAF-interacting protein with forkhead-associated domain
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354911
InnateDB Gene IDBG-34438 (TIFA)
Protein Structure
UniProt Annotation
Function Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. {ECO:0000269PubMed:12566447, ECO:0000269PubMed:15492226}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000253 Forkhead-associated (FHA) domain
IPR008984 SMAD/FHA domain
PFAM PF00498
PRINTS
PIRSF
SMART SM00240
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96CG3
PhosphoSite PhosphoSite-Q96CG3
TrEMBL
UniProt Splice Variant
Entrez Gene 92610
UniGene Hs.626166
RefSeq NP_443096
HUGO HGNC:19075
OMIM 609028
CCDS CCDS34051
HPRD 09835
IMGT
EMBL AB062110 AB097011 AB097038 AC109347 AK292900 BC014259 CH471057
GenPept AAH14259 AAY40963 BAB86902 BAC77364 BAC77391 BAF85589 EAX06273

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca