InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERAP1

Summary

InnateDB Protein

IDBP-34701.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERAP1

Protein Name

endoplasmic reticulum aminopeptidase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296754

InnateDB Gene

IDBG-34697 (ERAP1)

Protein Structure

UniProt Annotation

Function

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. {ECO:0000269PubMed:15908954, ECO:0000269PubMed:16286653, ECO:0000269PubMed:21478864}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305PubMed:15908954}; Single-pass type II membrane protein {ECO:0000305PubMed:15908954}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005138	interleukin-6 receptor binding
GO:0005151	interleukin-1, Type II receptor binding
GO:0005515	protein binding
GO:0008235	metalloexopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001525	angiogenesis
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0008217	regulation of blood pressure
GO:0009617	response to bacterium
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0045444	fat cell differentiation
GO:0045766	positive regulation of angiogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome