Version 5.4
Homo sapiens Gene: ERAP1
Summary
InnateDB Gene IDBG-34697.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERAP1
Gene Name endoplasmic reticulum aminopeptidase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164307
Encoded Proteins
IDBP-34701
endoplasmic reticulum aminopeptidase 1
IDBP-374062
endoplasmic reticulum aminopeptidase 1
IDBP-483024
endoplasmic reticulum aminopeptidase 1
IDBP-480231
endoplasmic reticulum aminopeptidase 1
IDBP-474837
endoplasmic reticulum aminopeptidase 1
IDBP-479565
endoplasmic reticulum aminopeptidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18445477
ERAP1 associates with RBMX and a heterogeneous nuclear ribonucleoprotein to regulate both the constitutive release of TNFR1 exosome-like vesicles and the inducible proteolytic cleavage of TNFR1 ectodomains.
Entrez Gene
Summary The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:96760810-96808100
Strand Reverse strand
Band q15
Transcripts
ENST00000296754 ENSP00000296754
ENST00000443439 ENSP00000406304
ENST00000512852 ENSP00000425381
ENST00000514604
ENST00000507859
ENST00000503311
ENST00000503921 ENSP00000427025
ENST00000508227 ENSP00000422631
ENST00000507154 ENSP00000421697
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0005138 interleukin-6 receptor binding
GO:0005151 interleukin-1, Type II receptor binding
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001525 angiogenesis
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0008217 regulation of blood pressure
GO:0009617 response to bacterium
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0045444 fat cell differentiation
GO:0045766 positive regulation of angiogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021583
View Gene Order
ENSBTAG00000013557
Not yet available
Pathways
NETPATH
REACTOME
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 51752
UniGene Hs.666524
RefSeq NM_001040458 NM_001198541 NM_016442 XM_005272015 XM_005272016
HUGO HGNC:18173
OMIM 606832
CCDS CCDS4085 CCDS47250
HPRD 06015
IMGT
EMBL
GenPept
RNA Seq Atlas 51752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca