Homo sapiens Protein: BSN
Summary
InnateDB Protein IDBP-34909.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BSN
Protein Name bassoon (presynaptic cytomatrix protein)
Synonyms ZNF231;
Species Homo sapiens
Ensembl Protein ENSP00000296452
InnateDB Gene IDBG-34907 (BSN)
Protein Structure
UniProt Annotation
Function Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density. {ECO:0000250}.
Disease Associations
Tissue Specificity Exclusively expressed in brain. {ECO:0000269PubMed:9806829}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007268 synaptic transmission
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0044306 neuron projection terminus
GO:0045202 synapse
GO:0048786 presynaptic active zone
Protein Structure and Domains
PDB ID
InterPro IPR008899 Zinc finger, piccolo-type
IPR011011 Zinc finger, FYVE/PHD-type
PFAM PF05715
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UPA5
PhosphoSite PhosphoSite-Q9UPA5
TrEMBL
UniProt Splice Variant
Entrez Gene 8927
UniGene Hs.194684
RefSeq NP_003449
HUGO HGNC:1117
OMIM 604020
CCDS CCDS2800
HPRD 04933
IMGT
EMBL AB007894 AC099668 AC104452 AF052224 Y18448 Y18449 Y18450 Y18451
GenPept AAC83555 BAA23707 CAA77176