Version 5.4
Homo sapiens Gene: BSN
Summary
InnateDB Gene IDBG-34907.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BSN
Gene Name bassoon (presynaptic cytomatrix protein)
Synonyms ZNF231;
Species Homo sapiens
Ensembl Gene ENSG00000164061
Encoded Proteins
IDBP-34909
bassoon (presynaptic cytomatrix protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49554489-49671545
Strand Forward strand
Band p21.31
Transcripts
ENST00000296452 ENSP00000296452
ENST00000467456
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007268 synaptic transmission
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0044306 neuron projection terminus
GO:0045202 synapse
GO:0048786 presynaptic active zone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000032589
View Gene Order
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000011581
Not yet available
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q9UPA5
TrEMBL
UniProt Splice Variant
Entrez Gene 8927
UniGene Hs.194684
RefSeq NM_003458 XM_006713380
HUGO HGNC:1117
OMIM 604020
CCDS CCDS2800
HPRD 04933
IMGT
EMBL AB007894 AC099668 AC104452 AF052224 Y18448 Y18449 Y18450 Y18451
GenPept AAC83555 BAA23707 CAA77176
RNA Seq Atlas 8927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca