InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP10

Summary

InnateDB Protein

IDBP-35164.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP10

Protein Name

A kinase (PRKA) anchor protein 10

Synonyms

AKAP-10; D-AKAP-2; D-AKAP2; PRKA10;

Species

Homo sapiens

Ensembl Protein

ENSP00000225737

InnateDB Gene

IDBG-35162 (AKAP10)

Protein Structure

UniProt Annotation

Function

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:11248059}. Membrane {ECO:0000269PubMed:11248059}. Cytoplasm {ECO:0000269PubMed:11248059}. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.

Disease Associations

Sudden cardiac death (SCD) [MIM:115080]: Unexpected rapid death due to cardiovascular collapse in a short time period, generally within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. {ECO:0000269PubMed:17485678}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008104	protein localization
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0045087	innate immune response (InnateDB)