Homo sapiens Gene: AKAP10
Summary
InnateDB Gene IDBG-35162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP10
Gene Name A kinase (PRKA) anchor protein 10
Synonyms AKAP-10; D-AKAP-2; D-AKAP2; PRKA10;
Species Homo sapiens
Ensembl Gene ENSG00000108599
Encoded Proteins
A kinase (PRKA) anchor protein 10
A kinase (PRKA) anchor protein 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
AKAP10 is required to induce PTGES2 in the synthesis of NO upon LPS stimulation, in addition AKAP10 also mediates the PTGES2-induced expression of cytokines IL10 and IL6 in alveolar macrophages. (Demonstrated in rat models)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Akap10 is required to induce Ptges2 in the synthesis of NO upon LPS stimulation, in addition Akap10 also mediates the Ptges2-induced expression of cytokines Il10 and Il6 in alveolar macrophages. (Demonstrated in rat models)
Entrez Gene
Summary This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:19904302-19978343
Strand Reverse strand
Band p11.2
Transcripts
ENST00000225737 ENSP00000225737
ENST00000395536 ENSP00000378907
ENST00000460046 ENSP00000464294
ENST00000474245
ENST00000571858 ENSP00000461793
ENST00000572155
ENST00000572341 ENSP00000461040
ENST00000582611 ENSP00000464079
ENST00000576896 ENSP00000458637
ENST00000578898 ENSP00000466329
ENST00000583951 ENSP00000463398
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0008104 protein localization
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B7Z2W6 I3L177
UniProt Splice Variant
Entrez Gene 11216
UniGene Hs.601523 Hs.642676 Hs.721282
RefSeq NM_007202 XM_006721433
HUGO HGNC:368
OMIM 604694
CCDS CCDS11214
HPRD 05259
IMGT
EMBL AC005730 AC015726 AK295180
GenPept BAH12002
RNA Seq Atlas 11216