InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AKAP10

Summary

InnateDB Gene

IDBG-35162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP10

Gene Name

A kinase (PRKA) anchor protein 10

Synonyms

AKAP-10; D-AKAP-2; D-AKAP2; PRKA10

Species

Homo sapiens

Ensembl Gene

ENSG00000108599

Encoded Proteins

IDBP-35164

A kinase (PRKA) anchor protein 10

IDBP-239354

A kinase (PRKA) anchor protein 10

IDBP-762946

IDBP-762551

IDBP-763215

IDBP-761032

IDBP-761215

IDBP-759397

IDBP-762472

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21247892

AKAP10 is required to induce PTGES2 in the synthesis of NO upon LPS stimulation, in addition AKAP10 also mediates the PTGES2-induced expression of cytokines IL10 and IL6 in alveolar macrophages. (Demonstrated in rat models)

InnateDB Annotation from Orthologs

Summary

PMID 21247892

[Mus musculus] Akap10 is required to induce Ptges2 in the synthesis of NO upon LPS stimulation, in addition Akap10 also mediates the Ptges2-induced expression of cytokines Il10 and Il6 in alveolar macrophages. (Demonstrated in rat models)

Entrez Gene

Summary

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:19904302-19978343

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000225737	ENSP00000225737
ENST00000395536	ENSP00000378907
ENST00000460046	ENSP00000464294
ENST00000474245
ENST00000571858	ENSP00000461793
ENST00000572155
ENST00000572341	ENSP00000461040
ENST00000582611	ENSP00000464079
ENST00000576896	ENSP00000458637
ENST00000578898	ENSP00000466329
ENST00000583951	ENSP00000463398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008104	protein localization
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000047804

View Gene Order

ENSBTAG00000003439

Not yet available

Pathways

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.601523 Hs.642676 Hs.721282

RefSeq

NM_007202 XM_006721433

HUGO

OMIM

CCDS

CCDS11214

HPRD

05259

IMGT

EMBL

GenPept

RNA Seq Atlas