InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SQLE

Summary

InnateDB Protein

IDBP-35251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SQLE

Protein Name

squalene epoxidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265896

InnateDB Gene

IDBG-35249 (SQLE)

Protein Structure

UniProt Annotation

Function

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.

Subcellular Localization

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004506	squalene monooxygenase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0006725	cellular aromatic compound metabolic process
GO:0008203	cholesterol metabolic process
GO:0010033	response to organic substance
GO:0016126	sterol biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR002938 Monooxygenase, FAD-binding
IPR003042 Aromatic-ring hydroxylase-like
IPR013698 Squalene epoxidase

PFAM

PF00070
PF01494
PF08491

PRINTS

PR00420

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14534