Homo sapiens Gene: SQLE
Summary
InnateDB Gene IDBG-35249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SQLE
Gene Name squalene epoxidase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104549
Encoded Proteins
squalene epoxidase
squalene epoxidase
squalene epoxidase
squalene epoxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:124998497-125022283
Strand Forward strand
Band q24.13
Transcripts
ENST00000265896 ENSP00000265896
ENST00000523430 ENSP00000430331
ENST00000521232 ENSP00000428239
ENST00000518931 ENSP00000429916
ENST00000520493
ENST00000518604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004506 squalene monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006725 cellular aromatic compound metabolic process
GO:0008203 cholesterol metabolic process
GO:0010033 response to organic substance
GO:0016126 sterol biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Metabolism pathway
KEGG
Steroid biosynthesis pathway
INOH
Steroids metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q14534
TrEMBL B4DHX0 E5RJH9 E7EVQ6 H0YBN7 Q9UNR6
UniProt Splice Variant
Entrez Gene 6713
UniGene Hs.597714 Hs.71465
RefSeq NM_003129
HUGO HGNC:11279
OMIM 602019
CCDS CCDS47918
HPRD
IMGT
EMBL AC009908 AF098865 AK295302 AK313384 BC017033 BX647400 CH471060 D78129 D78130 FJ695197
GenPept AAD10823 AAH17033 BAA11209 BAA22372 BAG36182 BAG58282 EAW92079
RNA Seq Atlas 6713