InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS36

Summary

InnateDB Protein

IDBP-35283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS36

Protein Name

vacuolar protein sorting 36 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000367299

InnateDB Gene

IDBG-35281 (VPS36)

Protein Structure

UniProt Annotation

Function

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. {ECO:0000269PubMed:15755741}.

Subcellular Localization

Cytoplasm. Endosome. Late endosome. Membrane. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0043130	ubiquitin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0061024	membrane organization

Cellular Component

GO:0005634	nucleus
GO:0005764	lysosome
GO:0005768	endosome
GO:0005770	late endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome