Version 5.4
Homo sapiens Gene: VPS36
Summary
InnateDB Gene IDBG-35281.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS36
Gene Name vacuolar protein sorting 36 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136100
Encoded Proteins
IDBP-35283
vacuolar protein sorting 36 homolog (S. cerevisiae)
IDBP-812066
vacuolar protein sorting 36 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary VPS36, VPS22 (SNF8; MIM 610904), and VPS25 (MIM 610907) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS36, VPS22, and VPS25 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:52412602-52450628
Strand Reverse strand
Band q14.3
Transcripts
ENST00000378060 ENSP00000367299
ENST00000497149
ENST00000462289
ENST00000492650
ENST00000480923
ENST00000475375
ENST00000611132 ENSP00000484968
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0043130 ubiquitin binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005768 endosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031479
View Gene Order
ENSBTAG00000004307
Not yet available
Pathways
NETPATH
REACTOME
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q86VN1
TrEMBL
UniProt Splice Variant
Entrez Gene 51028
UniGene Hs.602888 Hs.605793 Hs.609870 Hs.614569 Hs.718306
RefSeq NM_001282168 NM_001282169 NM_016075
HUGO HGNC:20312
OMIM 610903
CCDS CCDS73577 CCDS9434
HPRD
IMGT
EMBL AF151903 AK023182 AK289740 AL359513 BC037279 BC050439 CH471274 CR933653
GenPept AAD34140 AAH37279 AAH50439 BAB14451 BAF82429 CAH71658 CAI45953 EAW55895
RNA Seq Atlas 51028

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca