InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRSS12

Summary

InnateDB Protein

IDBP-35402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRSS12

Protein Name

protease, serine, 12 (neurotrypsin, motopsin)

Synonyms

BSSP-3; BSSP3; MRT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000296498

InnateDB Gene

IDBG-35400 (PRSS12)

Protein Structure

UniProt Annotation

Function

Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Mental retardation, autosomal recessive 1 (MRT1) [MIM:249500]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Brain and Leydig cells of the testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006887	exocytosis
GO:0006898	receptor-mediated endocytosis
GO:0031638	zymogen activation

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0043083	synaptic cleft
GO:0043195	terminal bouton
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold
IPR017448 SRCR-like domain

PFAM

PF00051
PF00530
PF00089

PRINTS

PR00258
PR00722

PIRSF

SMART

SM00130
SM00020
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt