Homo sapiens Gene: PRSS12
Summary
InnateDB Gene IDBG-35400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRSS12
Gene Name protease, serine, 12 (neurotrypsin, motopsin)
Synonyms BSSP-3; BSSP3; MRT1;
Species Homo sapiens
Ensembl Gene ENSG00000164099
Encoded Proteins
protease, serine, 12 (neurotrypsin, motopsin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:118280038-118353003
Strand Reverse strand
Band q26
Transcripts
ENST00000296498 ENSP00000296498
ENST00000510903
ENST00000515089
ENST00000503043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006887 exocytosis
GO:0006898 receptor-mediated endocytosis
GO:0031638 zymogen activation
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0043083 synaptic cleft
GO:0043195 terminal bouton
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P56730
TrEMBL
UniProt Splice Variant
Entrez Gene 8492
UniGene Hs.445857
RefSeq NM_003619 XM_005263318
HUGO HGNC:9477
OMIM 606709
CCDS CCDS3709
HPRD
IMGT
EMBL AC096762 AF077298 AJ001531
GenPept AAD25919 CAA04816
RNA Seq Atlas 8492