InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC24D

Summary

InnateDB Protein

IDBP-35526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC24D

Protein Name

SEC24 family, member D (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000280551

InnateDB Gene

IDBG-35522 (SEC24D)

Protein Structure

UniProt Annotation

Function

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008270	zinc ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0048208	COPII vesicle coating
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0030127	COPII vesicle coat
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR006895 Zinc finger, Sec23/Sec24-type
IPR006896 Sec23/Sec24, trunk domain
IPR006900 Sec23/Sec24, helical domain
IPR007123 Gelsolin-like domain
IPR012990 Sec23/Sec24 beta-sandwich

PFAM

PF00092
PF04810
PF04811
PF04815
PF00626
PF08033

PRINTS

PIRSF

SMART

SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O94855