InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOS2

Summary

InnateDB Protein

IDBP-36002.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOS2

Protein Name

nitric oxide synthase 2, inducible

Synonyms

HEP-NOS; INOS; NOS; NOS2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000327251

InnateDB Gene

IDBG-36000 (NOS2)

Protein Structure

UniProt Annotation

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	182 [view]
Protein-Protein	163 [view]
Protein-DNA	18 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004517	nitric-oxide synthase activity
GO:0005102	receptor binding
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0034617	tetrahydrobiopterin binding
GO:0034618	arginine binding
GO:0042803	protein homodimerization activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0001666	response to hypoxia
GO:0001912	positive regulation of leukocyte mediated cytotoxicity
GO:0002227	innate immune response in mucosa
GO:0006527	arginine catabolic process
GO:0006801	superoxide metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0006954	inflammatory response
GO:0007263	nitric oxide mediated signal transduction
GO:0007596	blood coagulation
GO:0007623	circadian rhythm
GO:0009617	response to bacterium
GO:0010629	negative regulation of gene expression
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0031284	positive regulation of guanylate cyclase activity
GO:0032496	response to lipopolysaccharide
GO:0042127	regulation of cell proliferation
GO:0042177	negative regulation of protein catabolic process
GO:0042742	defense response to bacterium
GO:0043457	regulation of cellular respiration
GO:0045087	innate immune response (InnateDB)
GO:0045776	negative regulation of blood pressure
GO:0045909	positive regulation of vasodilation
GO:0050796	regulation of insulin secretion
GO:0050829	defense response to Gram-negative bacterium
GO:0051701	interaction with host
GO:0051712	positive regulation of killing of cells of other organism
GO:0055114	oxidation-reduction process
GO:0071222	cellular response to lipopolysaccharide
GO:0071346	cellular response to interferon-gamma
GO:0090382	phagosome maturation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0030863	cortical cytoskeleton
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR004030 Nitric oxide synthase, N-terminal
IPR008254 Flavodoxin/nitric oxide synthase
IPR012144 Nitric-oxide synthase, eukaryote
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like

PFAM

PF00175
PF00667
PF02898
PF00258

PRINTS

PR00369
PR00371

PIRSF

PIRSF000333

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt