InnateDB Protein
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IDBP-360711.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPON2
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Protein Name
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spondin 2, extracellular matrix protein
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Synonyms
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DIL-1; DIL1; M-SPONDIN; MINDIN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000394832
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InnateDB Gene
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IDBG-6462 (SPON2)
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Protein Structure
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Function |
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in normal lung tissue but not in lung carcinoma cell lines. {ECO:0000269PubMed:10512675}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000884
Thrombospondin, type 1 repeat
IPR009465
Spondin, N-terminal
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PFAM |
PF00090
PF06468
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PRINTS |
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PIRSF |
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SMART |
SM00209
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BUD6
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PhosphoSite |
PhosphoSite-Q9BUD6
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TrEMBL |
D6RIH5
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UniProt Splice Variant |
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Entrez Gene |
10417
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UniGene |
Hs.743914
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RefSeq |
NP_001121797
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HUGO |
HGNC:11253
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OMIM |
605918
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CCDS |
CCDS3347
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HPRD |
16174
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IMGT |
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EMBL |
AB027466
AC092535
AK074618
AK074770
AY358948
BC002707
BC036341
CH471131
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GenPept |
AAH02707
AAH36341
AAQ89307
AAY40988
BAA85892
BAC11092
BAC11196
EAW82604
EAW82606
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