Homo sapiens Gene: SPON2
Summary
InnateDB Gene IDBG-6462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPON2
Gene Name spondin 2, extracellular matrix protein
Synonyms DIL-1; DIL1; M-SPONDIN; MINDIN;
Species Homo sapiens
Ensembl Gene ENSG00000159674
Encoded Proteins
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
spondin 2, extracellular matrix protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SPON2 expression is upregulated during intestinal inflammation and may induce NF-kappaB promoter activation in a TLR-9 mediated manner.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:1166932-1208962
Strand Reverse strand
Band p16.3
Transcripts
ENST00000290902 ENSP00000290902
ENST00000400762
ENST00000431380 ENSP00000394832
ENST00000509697
ENST00000507466
ENST00000503765 ENSP00000424542
ENST00000504909
ENST00000512888
ENST00000512150
ENST00000515004 ENSP00000425871
ENST00000502483 ENSP00000422516
ENST00000514490 ENSP00000421634
ENST00000509233 ENSP00000421379
ENST00000511679 ENSP00000423414
ENST00000511672 ENSP00000421858
ENST00000506266
ENST00000504871
ENST00000502657
ENST00000505653
ENST00000515553
ENST00000510542
ENST00000617421 ENSP00000483599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0003823 antigen binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002448 mast cell mediated immunity
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0008228 opsonization
GO:0032496 response to lipopolysaccharide
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042742 defense response to bacterium
GO:0043152 induction of bacterial agglutination
GO:0045087 innate immune response (InnateDB)
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0060907 positive regulation of macrophage cytokine production
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.302963 Hs.743914
RefSeq NM_001128325 NM_001199021 NM_012445
HUGO
OMIM
CCDS CCDS3347
HPRD 16174
IMGT
EMBL
GenPept
RNA Seq Atlas