InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPON2

Summary

InnateDB Gene

IDBG-6462.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPON2

Gene Name

spondin 2, extracellular matrix protein

Synonyms

DIL-1; DIL1; M-SPONDIN; MINDIN

Species

Homo sapiens

Ensembl Gene

ENSG00000159674

Encoded Proteins

IDBP-6466

spondin 2, extracellular matrix protein

IDBP-360711

spondin 2, extracellular matrix protein

IDBP-481608

spondin 2, extracellular matrix protein

IDBP-475699

spondin 2, extracellular matrix protein

IDBP-478693

spondin 2, extracellular matrix protein

IDBP-484659

spondin 2, extracellular matrix protein

IDBP-480404

spondin 2, extracellular matrix protein

IDBP-473433

spondin 2, extracellular matrix protein

IDBP-478952

spondin 2, extracellular matrix protein

IDBP-806860

spondin 2, extracellular matrix protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20205276

SPON2 expression is upregulated during intestinal inflammation and may induce NF-kappaB promoter activation in a TLR-9 mediated manner.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:1166932-1208962

Strand

Reverse strand

Band

p16.3

Transcripts

ENST00000290902	ENSP00000290902
ENST00000400762
ENST00000431380	ENSP00000394832
ENST00000509697
ENST00000507466
ENST00000503765	ENSP00000424542
ENST00000504909
ENST00000512888
ENST00000512150
ENST00000515004	ENSP00000425871
ENST00000502483	ENSP00000422516
ENST00000514490	ENSP00000421634
ENST00000509233	ENSP00000421379
ENST00000511679	ENSP00000423414
ENST00000511672	ENSP00000421858
ENST00000506266
ENST00000504871
ENST00000502657
ENST00000505653
ENST00000515553
ENST00000510542
ENST00000617421	ENSP00000483599

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0003823	antigen binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002448	mast cell mediated immunity
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0008228	opsonization
GO:0032496	response to lipopolysaccharide
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042742	defense response to bacterium
GO:0043152	induction of bacterial agglutination
GO:0045087	innate immune response (InnateDB)
GO:0050832	defense response to fungus
GO:0051607	defense response to virus
GO:0060907	positive regulation of macrophage cytokine production
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037379

View Gene Order

ENSBTAG00000004261

Not yet available

Pathways

NETPATH

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_200727

O-linked glycosylation pathway

REACT_17015

Metabolism of proteins pathway

REACT_200626

O-glycosylation of TSR domain-containing proteins pathway

KEGG

INOH

PID NCI

integrin2_pathway

Beta2 integrin cell surface interactions

Cross-References

SwissProt

TrEMBL

D6RB12 D6RBY3 D6REX2 D6RIH5

UniProt Splice Variant

Entrez Gene

10417

UniGene

RefSeq

NM_001199021 NM_001128325 NM_012445

HUGO

HGNC:11253

OMIM

605918

CCDS

CCDS3347

HPRD

IMGT

EMBL

AC092535

GenPept

RNA Seq Atlas

100130872 10417