InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEIL2

Summary

InnateDB Protein

IDBP-360974.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEIL2

Protein Name

nei endonuclease VIII-like 2 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000397538

InnateDB Gene

IDBG-7513 (NEIL2)

Protein Structure

UniProt Annotation

Function

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO:0000269PubMed:12097317, ECO:0000269PubMed:14522990, ECO:0000269PubMed:15175427, ECO:0000269PubMed:15339932}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12097317}.

Disease Associations

Tissue Specificity

Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver. {ECO:0000269PubMed:12097317}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003684	damaged DNA binding
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0008270	zinc ion binding
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000214 Zinc finger, DNA glycosylase/AP lyase-type
IPR010979 Ribosomal protein S13-like, H2TH
IPR012319 DNA glycosylase/AP lyase, catalytic domain
IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding

PFAM

PF01149
PF06831

PRINTS

PIRSF

SMART

SM00898

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q969S2