Homo sapiens Gene: NEIL2
Summary
InnateDB Gene IDBG-7513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEIL2
Gene Name nei endonuclease VIII-like 2 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154328
Encoded Proteins
nei endonuclease VIII-like 2 (E. coli)
nei endonuclease VIII-like 2 (E. coli)
nei endonuclease VIII-like 2 (E. coli)
nei endonuclease VIII-like 2 (E. coli)
nei endonuclease VIII-like 2 (E. coli)
nei endonuclease VIII-like 2 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:11769639-11787346
Strand Forward strand
Band p23.1
Transcripts
ENST00000284503 ENSP00000284503
ENST00000403422 ENSP00000384070
ENST00000436750 ENSP00000394023
ENST00000455213 ENSP00000397538
ENST00000528113 ENSP00000437004
ENST00000528323 ENSP00000435657
ENST00000524741
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.293818
RefSeq NM_001135746 NM_001135747 NM_001135748 NM_145043 XM_005272381 XM_005272382 XM_005272383
HUGO
OMIM
CCDS CCDS47802 CCDS47803 CCDS5984
HPRD 16406
IMGT
EMBL
GenPept
RNA Seq Atlas