Version 5.4
Homo sapiens Gene: NEIL2
Summary
InnateDB Gene IDBG-7513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEIL2
Gene Name nei endonuclease VIII-like 2 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154328
Encoded Proteins
IDBP-7515
nei endonuclease VIII-like 2 (E. coli)
IDBP-292520
nei endonuclease VIII-like 2 (E. coli)
IDBP-360973
nei endonuclease VIII-like 2 (E. coli)
IDBP-360974
nei endonuclease VIII-like 2 (E. coli)
IDBP-596966
nei endonuclease VIII-like 2 (E. coli)
IDBP-598106
nei endonuclease VIII-like 2 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:11769639-11787346
Strand Forward strand
Band p23.1
Transcripts
ENST00000284503 ENSP00000284503
ENST00000403422 ENSP00000384070
ENST00000436750 ENSP00000394023
ENST00000455213 ENSP00000397538
ENST00000528113 ENSP00000437004
ENST00000528323 ENSP00000435657
ENST00000524741
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035121
View Gene Order
ENSBTAG00000004769
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.293818
RefSeq NM_001135746 NM_001135747 NM_001135748 NM_145043 XM_005272381 XM_005272382 XM_005272383
HUGO
OMIM
CCDS CCDS47802 CCDS47803 CCDS5984
HPRD 16406
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca