InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADD1

Summary

InnateDB Protein

IDBP-361138.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADD1

Protein Name

adducin 1 (alpha)

Synonyms

ADDA;

Species

Homo sapiens

Ensembl Protein

ENSP00000399828

InnateDB Gene

IDBG-7701 (ADD1)

Protein Structure

UniProt Annotation

Function

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005516	calmodulin binding
GO:0008134	transcription factor binding
GO:0030507	spectrin binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030036	actin cytoskeleton organization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032092	positive regulation of protein binding
GO:0044267	cellular protein metabolic process
GO:0051016	barbed-end actin filament capping
GO:0051017	actin filament bundle assembly