Homo sapiens Protein: MAPT
InnateDB Protein IDBP-361465.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPT
Protein Name microtubule-associated protein tau
Species Homo sapiens
Ensembl Protein ENSP00000408975
InnateDB Gene IDBG-55163 (MAPT)
Protein Structure
UniProt Annotation
Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269PubMed:21985311}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:10747907}. Cell membrane {ECO:0000269PubMed:10747907}; Peripheral membrane protein {ECO:0000269PubMed:10747907}; Cytoplasmic side {ECO:0000269PubMed:10747907}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10747907}. Cell projection, axon {ECO:0000269PubMed:10747907}. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Disease Associations Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P- TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylations. {ECO:0000269PubMed:14517953}.Frontotemporal dementia (FTD) [MIM:600274]: A form of dementia characterized by pathologic finding of frontotemporal lobar degeneration, presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons. {ECO:0000269PubMed:10208578, ECO:0000269PubMed:10214944, ECO:0000269PubMed:10489057, ECO:0000269PubMed:10553987, ECO:0000269PubMed:10802785, ECO:0000269PubMed:11071507, ECO:0000269PubMed:11117541, ECO:0000269PubMed:11585254, ECO:0000269PubMed:11889249, ECO:0000269PubMed:11921059, ECO:0000269PubMed:12473774, ECO:0000269PubMed:12509859, ECO:0000269PubMed:15883319, ECO:0000269PubMed:16240366, ECO:0000269PubMed:9629852, ECO:0000269PubMed:9641683, ECO:0000269PubMed:9736786, ECO:0000269PubMed:9789048, ECO:0000269PubMed:9973279}. Note=The disease is caused by mutations affecting the gene represented in this entry.Pick disease of the brain (PIDB) [MIM:172700]: A rare form of dementia pathologically defined by severe atrophy, neuronal loss and gliosis. It is characterized by the occurrence of tau-positive inclusions, swollen neurons (Pick cells) and argentophilic neuronal inclusions known as Pick bodies that disproportionally affect the frontal and temporal cortical regions. Clinical features include aphasia, apraxia, confusion, anomia, memory loss and personality deterioration. {ECO:0000269PubMed:10604746, ECO:0000269PubMed:11089577, ECO:0000269PubMed:11117542, ECO:0000269PubMed:11601501, ECO:0000269PubMed:11891833}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.Progressive supranuclear palsy 1 (PSNP1) [MIM:601104]: Characterized by akinetic-rigid syndrome, supranuclear gaze palsy, pyramidal tract dysfunction, pseudobulbar signs and cognitive capacities deterioration. Neurofibrillary tangles and gliosis but no amyloid plaques are found in diseased brains. Most cases appear to be sporadic, with a significant association with a common haplotype including the MAPT gene and the flanking regions. Familial cases show an autosomal dominant pattern of transmission with incomplete penetrance; genetic analysis of a few cases showed the occurrence of tau mutations, including a deletion of Asn-613. {ECO:0000269PubMed:10534245, ECO:0000269PubMed:11220749, ECO:0000269PubMed:12325083, ECO:0000269PubMed:14991828, ECO:0000269PubMed:14991829, ECO:0000269PubMed:16157753}. Note=The disease is caused by mutations affecting the gene represented in this entry.Parkinson-dementia syndrome (PARDE) [MIM:260540]: A syndrome characterized by parkinsonism, tremor, rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus, basal ganglia and brainstem nuclei. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Number of Interactions This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 129 [view]
Protein-Protein 128 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0034185 apolipoprotein binding
GO:0071813 lipoprotein particle binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007026 negative regulation of microtubule depolymerization
GO:0010506 regulation of autophagy
GO:0031113 regulation of microtubule polymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0045773 positive regulation of axon extension
GO:0048699 generation of neurons
Cellular Component
GO:0005829 cytosol
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0034399 nuclear periphery
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0045298 tubulin complex
Protein Structure and Domains
InterPro IPR001084 Microtubule associated protein, tubulin-binding repeat
IPR002955 Microtubule-associated protein Tau
PFAM PF00418
Post-translational Modifications
SwissProt P10636
PhosphoSite PhosphoSite-P10636
UniProt Splice Variant
Entrez Gene 4137
UniGene Hs.101174
RefSeq NP_058518
OMIM 157140
HPRD 01142
EMBL AC004139 AC010792 AC217771 AC217779 AF027491 AF027492 AF027493 AF027494 AF027495 AF027496 AF047856 AF047857 AF047858 AF047859 AF047860 AF047861 AF047862 AF047863 AY526356 AY730549 BC000558 BC098281 BC099721 BC101936 BC114504 BC114948 BN000503 BT006772 CH471233 J03778 M25298 X14474
GenPept AAA57264 AAA60615 AAC04277 AAC04278 AAC04279 AAH00558 AAH98281 AAH99721 AAI01937 AAI14505 AAI14949 AAP35418 AAS17881 AAU45390 CAA32636 CAG26750 EAW93566 EAW93568