InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MBD3

Summary

InnateDB Protein

IDBP-362338.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBD3

Protein Name

methyl-CpG binding domain protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000412302

InnateDB Gene

IDBG-14805 (MBD3)

Protein Structure

UniProt Annotation

Function

Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. {ECO:0000269PubMed:10947852, ECO:0000269PubMed:12124384, ECO:0000269PubMed:18644863, ECO:0000269PubMed:23361464, ECO:0000269PubMed:24307175, ECO:0000269PubMed:9774669}.

Subcellular Localization

Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	90 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006346	methylation-dependent chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0009888	tissue development
GO:0016573	histone acetylation
GO:0043044	ATP-dependent chromatin remodeling

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016581	NuRD complex
GO:0043234	protein complex