Homo sapiens Gene: MBD3
Summary
InnateDB Gene IDBG-14805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBD3
Gene Name methyl-CpG binding domain protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000071655
Encoded Proteins
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
methyl-CpG binding domain protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1573596-1592801
Strand Reverse strand
Band p13.3
Transcripts
ENST00000156825 ENSP00000156825
ENST00000434436 ENSP00000412302
ENST00000585967 ENSP00000484202
ENST00000592965 ENSP00000482276
ENST00000585903 ENSP00000479427
ENST00000590550 ENSP00000464718
ENST00000592012 ENSP00000466670
ENST00000592361 ENSP00000477547
ENST00000589064
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 95 [view]
Protein-Protein 90 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005488 binding
GO:0005515 protein binding
GO:0008327 methyl-CpG binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006346 methylation-dependent chromatin silencing
GO:0006351 transcription, DNA-templated
GO:0009888 tissue development
GO:0016573 histone acetylation
GO:0043044 ATP-dependent chromatin remodeling
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016581 NuRD complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase I Transcription pathway
RNA Polymerase I Promoter Clearance pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
RNA Polymerase I Transcription Initiation pathway
Chromatin modifying enzymes pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
Downregulated of mta-3 in er-negative breast tumors [Biocarta view]
Mechanisms of transcriptional repression by dna methylation [Biocarta view]
PID NCI
Signaling events mediated by HDAC Class I
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.178728
RefSeq NM_001281453 NM_001281454
HUGO
OMIM
CCDS CCDS12072 CCDS62481
HPRD 04653
IMGT
EMBL
GenPept
RNA Seq Atlas