InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MBD3

Summary

InnateDB Gene

IDBG-14805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBD3

Gene Name

methyl-CpG binding domain protein 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000071655

Encoded Proteins

IDBP-14809

methyl-CpG binding domain protein 3

IDBP-362338

methyl-CpG binding domain protein 3

IDBP-808562

methyl-CpG binding domain protein 3

IDBP-808564

methyl-CpG binding domain protein 3

IDBP-808561

methyl-CpG binding domain protein 3

IDBP-760205

IDBP-766028

IDBP-808563

methyl-CpG binding domain protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:1573596-1592801

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000156825	ENSP00000156825
ENST00000434436	ENSP00000412302
ENST00000585967	ENSP00000484202
ENST00000592965	ENSP00000482276
ENST00000585903	ENSP00000479427
ENST00000590550	ENSP00000464718
ENST00000592012	ENSP00000466670
ENST00000592361	ENSP00000477547
ENST00000589064

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	90 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006346	methylation-dependent chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0009888	tissue development
GO:0016573	histone acetylation
GO:0043044	ATP-dependent chromatin remodeling

Cellular Component

GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016581	NuRD complex
GO:0043234	protein complex