InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPRE3

Summary

InnateDB Protein

IDBP-36357.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPRE3

Protein Name

microtubule-associated protein, RP/EB family, member 3

Synonyms

EB3; EBF3; EBF3-S; RP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000233121

InnateDB Gene

IDBG-36353 (MAPRE3)

Protein Structure

UniProt Annotation

Function

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:10644998, ECO:0000269PubMed:19255245}. Note=Associated with the microtubule network. Detected at the plus end of microtubules.

Disease Associations

Tissue Specificity

Predominantly expressed in brain and muscle. {ECO:0000269PubMed:10644998}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:1903033	positive regulation of microtubule plus-end binding

Cellular Component

GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton
GO:0030496	midbody
GO:0035371	microtubule plus-end
GO:0048471	perinuclear region of cytoplasm