InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PFDN5

Summary

InnateDB Protein

IDBP-36380.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFDN5

Protein Name

prefoldin subunit 5

Synonyms

MM-1; MM1; PFD5;

Species

Homo sapiens

Ensembl Protein

ENSP00000334188

InnateDB Gene

IDBG-36378 (PFDN5)

Protein Structure

UniProt Annotation

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. {ECO:0000269PubMed:9630229}.

Subcellular Localization

Isoform 1: Nucleus.Isoform 2: Cytoplasm.Isoform 3: Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in pancreas and skeletal muscle and moderately in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006457	protein folding
GO:0044267	cellular protein metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051084	'de novo' posttranslational protein folding
GO:0090090	negative regulation of canonical Wnt signaling pathway