Homo sapiens Gene: PFDN5
Summary
InnateDB Gene IDBG-36378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN5
Gene Name prefoldin subunit 5
Synonyms MM-1; MM1; PFD5;
Species Homo sapiens
Ensembl Gene ENSG00000123349
Encoded Proteins
prefoldin subunit 5
prefoldin subunit 5
prefoldin subunit 5
prefoldin subunit 5
prefoldin subunit 5
prefoldin subunit 5
prefoldin subunit 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53295291-53299450
Strand Forward strand
Band q13.13
Transcripts
ENST00000334478 ENSP00000334188
ENST00000351500 ENSP00000266964
ENST00000243040 ENSP00000243040
ENST00000551018 ENSP00000447942
ENST00000550880 ENSP00000450068
ENST00000550069
ENST00000550846 ENSP00000454489
ENST00000551223
ENST00000552341
ENST00000547130 ENSP00000449388
ENST00000549995
ENST00000552742 ENSP00000450380
ENST00000550513
ENST00000547228
ENST00000549759 ENSP00000455296
ENST00000552548
ENST00000550964
ENST00000548984
ENST00000553171
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
Experimentally validated
Total 79 [view]
Protein-Protein 77 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006457 protein folding
GO:0044267 cellular protein metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051084 'de novo' posttranslational protein folding
GO:0060041 retina development in camera-type eye
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016272 prefoldin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Protein folding pathway
Chaperonin-mediated protein folding pathway
Metabolism of proteins pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID BIOCARTA
PID NCI
p73 transcription factor network
Cross-References
SwissProt Q99471
TrEMBL
UniProt Splice Variant
Entrez Gene 5204
UniGene Hs.655327
RefSeq NM_002624 NM_145897
HUGO HGNC:8869
OMIM 604899
CCDS CCDS8853 CCDS8854
HPRD
IMGT
EMBL AB055802 AB055803 AB055804 AB055805 AC073611 AK292623 BC003373 BC062671 BT007195 CH471054 D89667
GenPept AAH62671 AAP35859 BAA14006 BAB32643 BAB32644 BAB32645 BAB32646 BAF85312 EAW96683 EAW96685
RNA Seq Atlas 5204