InnateDB Protein
|
IDBP-363879.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SPIRE1
|
Protein Name
|
spire homolog 1 (Drosophila)
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000404752
|
InnateDB Gene
|
IDBG-1137 (SPIRE1)
|
Protein Structure
|
|
Function |
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269PubMed:11747823, ECO:0000269PubMed:21620703}.
|
Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:11747823}. Cytoplasm, perinuclear region {ECO:0000269PubMed:11747823}. Cell membrane {ECO:0000269PubMed:11747823}; Peripheral membrane protein {ECO:0000269PubMed:11747823}; Cytoplasmic side {ECO:0000269PubMed:11747823}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR011011
Zinc finger, FYVE/PHD-type
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q08AE8
|
PhosphoSite |
PhosphoSite-Q08AE8
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
56907
|
UniGene |
Hs.708220
|
RefSeq |
|
HUGO |
HGNC:30622
|
OMIM |
609216
|
CCDS |
|
HPRD |
11600
|
IMGT |
|
EMBL |
AB032961
AJ277587
AK290180
AL833817
AP001028
AP001029
AP005482
BC115005
BC125206
BC125207
CH471113
|
GenPept |
AAI15006
AAI25207
AAI25208
BAA86449
BAF82869
CAB96370
CAD38680
EAX01546
|
|
|