Version 5.4
Homo sapiens Gene: SPIRE1
Summary
InnateDB Gene IDBG-1137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPIRE1
Gene Name spire homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134278
Encoded Proteins
IDBP-1139
spire homolog 1 (Drosophila)
IDBP-292517
spire homolog 1 (Drosophila)
IDBP-292518
spire homolog 1 (Drosophila)
IDBP-363876
spire homolog 1 (Drosophila)
IDBP-363879
spire homolog 1 (Drosophila)
IDBP-363885
spire homolog 1 (Drosophila)
IDBP-725595
IDBP-726255
IDBP-725858
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:12446512-12658134
Strand Reverse strand
Band p11.21
Transcripts
ENST00000309836 ENSP00000309661
ENST00000409402 ENSP00000387266
ENST00000410092 ENSP00000387226
ENST00000453447 ENSP00000407050
ENST00000440472 ENSP00000404752
ENST00000449797 ENSP00000401392
ENST00000498803
ENST00000464481
ENST00000487491
ENST00000497844 ENSP00000467103
ENST00000462226 ENSP00000467943
ENST00000588236
ENST00000592156 ENSP00000466531
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030036 actin cytoskeleton organization
GO:0036089 cleavage furrow formation
GO:0040038 polar body extrusion after meiotic divisions
GO:0046907 intracellular transport
GO:0048193 Golgi vesicle transport
GO:0051295 establishment of meiotic spindle localization
GO:0070649 formin-nucleated actin cable assembly
Cellular Component
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0030659 cytoplasmic vesicle membrane
GO:0032154 cleavage furrow
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024533
View Gene Order
ENSBTAG00000010542
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515283 Hs.617285 Hs.708220
RefSeq NM_001128626 NM_001128627 NM_020148
HUGO
OMIM
CCDS CCDS32790 CCDS45829 CCDS45830
HPRD 11600
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca