InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENTPD4

Summary

InnateDB Protein

IDBP-363901.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENTPD4

Protein Name

ectonucleoside triphosphate diphosphohydrolase 4

Synonyms

LALP70; LAP70; LYSAL1; NTPDase-4; UDPase;

Species

Homo sapiens

Ensembl Protein

ENSP00000408573

InnateDB Gene

IDBG-11911 (ENTPD4)

Protein Structure

UniProt Annotation

Function

Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes in the Golgi and autophagic vacuoles/lysosomes.

Disease Associations

Tissue Specificity

Ubiquitous. Highest expression in testis and lowest in bladder.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016787	hydrolase activity
GO:0045134	uridine-diphosphatase activity

Biological Process

GO:0006256	UDP catabolic process
GO:0008152	metabolic process

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0030173	integral component of Golgi membrane
GO:0031410	cytoplasmic vesicle
GO:0043231	intracellular membrane-bounded organelle