Homo sapiens Gene: ENTPD4
Summary
InnateDB Gene IDBG-11911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD4
Gene Name ectonucleoside triphosphate diphosphohydrolase 4
Synonyms LALP70; LAP70; LYSAL1; NTPDase-4; UDPase;
Species Homo sapiens
Ensembl Gene ENSG00000197217
Encoded Proteins
ectonucleoside triphosphate diphosphohydrolase 4
ectonucleoside triphosphate diphosphohydrolase 4
ectonucleoside triphosphate diphosphohydrolase 4
ectonucleoside triphosphate diphosphohydrolase 4
ectonucleoside triphosphate diphosphohydrolase 4
ectonucleoside triphosphate diphosphohydrolase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:23385783-23457695
Strand Reverse strand
Band p21.3
Transcripts
ENST00000356206 ENSP00000348536
ENST00000358689 ENSP00000351520
ENST00000417069 ENSP00000408573
ENST00000518471 ENSP00000430579
ENST00000521321
ENST00000522255
ENST00000523958
ENST00000522913
ENST00000520936
ENST00000519839 ENSP00000427724
ENST00000518718 ENSP00000429455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0045134 uridine-diphosphatase activity
Biological Process
GO:0006256 UDP catabolic process
GO:0008152 metabolic process
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0030173 integral component of Golgi membrane
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Not yet available
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
Lysosome pathway
INOH
Purine nucleotides nucleosides metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YBY8
UniProt Splice Variant
Entrez Gene 9583
UniGene Hs.444389 Hs.626124
RefSeq NM_004901 NM_001128930
HUGO HGNC:14573
OMIM 607577
CCDS CCDS6041 CCDS47827
HPRD 09618
IMGT
EMBL AC104561
GenPept
RNA Seq Atlas 9583