Version 5.4
Homo sapiens Gene: ENTPD4
Summary
InnateDB Gene IDBG-11911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD4
Gene Name ectonucleoside triphosphate diphosphohydrolase 4
Synonyms LALP70; LAP70; LYSAL1; NTPDase-4; UDPase
Species Homo sapiens
Ensembl Gene ENSG00000197217
Encoded Proteins
IDBP-11913
ectonucleoside triphosphate diphosphohydrolase 4
IDBP-11917
ectonucleoside triphosphate diphosphohydrolase 4
IDBP-363901
ectonucleoside triphosphate diphosphohydrolase 4
IDBP-477121
ectonucleoside triphosphate diphosphohydrolase 4
IDBP-474389
ectonucleoside triphosphate diphosphohydrolase 4
IDBP-483437
ectonucleoside triphosphate diphosphohydrolase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:23385783-23457695
Strand Reverse strand
Band p21.3
Transcripts
ENST00000356206 ENSP00000348536
ENST00000358689 ENSP00000351520
ENST00000417069 ENSP00000408573
ENST00000518471 ENSP00000430579
ENST00000521321
ENST00000522255
ENST00000523958
ENST00000522913
ENST00000520936
ENST00000519839 ENSP00000427724
ENST00000518718 ENSP00000429455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0045134 uridine-diphosphatase activity
Biological Process
GO:0006256 UDP catabolic process
GO:0008152 metabolic process
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0030173 integral component of Golgi membrane
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
ENSBTAG00000006768
Not yet available
ENSMUSG00000095463
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa04142
Lysosome pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444389 Hs.626124
RefSeq NM_001128930 NM_004901
HUGO
OMIM
CCDS CCDS47827 CCDS6041
HPRD 09618
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca