InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOHH

Summary

InnateDB Protein

IDBP-364087.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOHH

Protein Name

deoxyhypusine hydroxylase/monooxygenase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000398882

InnateDB Gene

IDBG-17222 (DOHH)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor. {ECO:0000255HAMAP-Rule:MF_03101, ECO:0000269PubMed:16371467, ECO:0000269PubMed:19706422}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0019135	deoxyhypusine monooxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0055114	oxidation-reduction process