InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM5

Summary

InnateDB Protein

IDBP-364274.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM5

Protein Name

tripartite motif containing 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000393052

InnateDB Gene

IDBG-27690 (TRIM5)

Protein Structure

UniProt Annotation

Function

Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF- kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equine infectious anemia virus (EIAV). {ECO:0000269PubMed:12878161, ECO:0000269PubMed:18312418, ECO:0000269PubMed:21035162, ECO:0000269PubMed:21512573, ECO:0000269PubMed:21632761, ECO:0000269PubMed:22291694}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:12878161, ECO:0000269PubMed:20357094}. Note=Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Colocalizes with SQSTM1 in cytoplasmic bodies. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	52 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008329	signaling pattern recognition receptor activity
GO:0016874	ligase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0002218	activation of innate immune response
GO:0002221	pattern recognition receptor signaling pathway
GO:0016032	viral process
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0070206	protein trimerization
GO:0070534	protein K63-linked ubiquitination
GO:1902187	negative regulation of viral release from host cell