InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACTIN

Summary

InnateDB Protein

IDBP-364403.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACTIN

Protein Name

chromosome 19 open reading frame 29

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000415078

InnateDB Gene

IDBG-17610 (CACTIN)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. {ECO:0000269PubMed:20829348}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20829348}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001933	negative regulation of protein phosphorylation
GO:0007275	multicellular organismal development
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032688	negative regulation of interferon-beta production
GO:0032717	negative regulation of interleukin-8 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0060339	negative regulation of type I interferon-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor