Version 5.4
Homo sapiens Gene: CACTIN
Summary
InnateDB Gene IDBG-17610.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACTIN
Gene Name cactin, spliceosome C complex subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105298
Encoded Proteins
IDBP-17612
chromosome 19 open reading frame 29
IDBP-17614
chromosome 19 open reading frame 29
IDBP-364403
chromosome 19 open reading frame 29
IDBP-759724
IDBP-764278
IDBP-760540
IDBP-763992
IDBP-761780
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20829348
C19orf29 (Cactin) is a novel negative regulator of TLR signalling that targets the MHC class III protein I{kappa}B like (I{kappa}BL) and inhibits NFkappaB and IRF signalling pathways.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3610641-3626815
Strand Reverse strand
Band p13.3
Transcripts
ENST00000248420 ENSP00000248420
ENST00000221899 ENSP00000221899
ENST00000429344 ENSP00000415078
ENST00000587175
ENST00000588749 ENSP00000467788
ENST00000591726 ENSP00000464898
ENST00000591978
ENST00000592721 ENSP00000467149
ENST00000585942 ENSP00000465751
ENST00000589321 ENSP00000466600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0001933 negative regulation of protein phosphorylation
GO:0007275 multicellular organismal development
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032688 negative regulation of interferon-beta production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034889
View Gene Order
ENSBTAG00000010373
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.128425 Hs.729778
RefSeq NM_001080543 NM_021231
HUGO
OMIM
CCDS CCDS45920
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca