InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RFC3

Summary

InnateDB Protein

IDBP-364423.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFC3

Protein Name

replication factor C (activator 1) 3, 38kDa

Synonyms

RFC38;

Species

Homo sapiens

Ensembl Protein

ENSP00000401001

InnateDB Gene

IDBG-23475 (RFC3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	41 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003689	DNA clamp loader activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0000731	DNA synthesis involved in DNA repair
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0032201	telomere maintenance via semi-conservative replication
GO:0046683	response to organophosphorus

Cellular Component

GO:0005654	nucleoplasm
GO:0005663	DNA replication factor C complex
GO:0009360	DNA polymerase III complex

Protein Structure and Domains

PDB ID

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
IPR010372 DNA polymerase III, delta
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304
PF06144

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P40938