Homo sapiens Gene: RFC3
Summary
InnateDB Gene IDBG-23475.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFC3
Gene Name replication factor C (activator 1) 3, 38kDa
Synonyms RFC38;
Species Homo sapiens
Ensembl Gene ENSG00000133119
Encoded Proteins
replication factor C (activator 1) 3, 38kDa
replication factor C (activator 1) 3, 38kDa
replication factor C (activator 1) 3, 38kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:33818049-33966558
Strand Forward strand
Band q13.2
Transcripts
ENST00000380071 ENSP00000369411
ENST00000434425 ENSP00000401001
ENST00000616236 ENSP00000484747
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 41 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0000731 DNA synthesis involved in DNA repair
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0032201 telomere maintenance via semi-conservative replication
GO:0046683 response to organophosphorus
Cellular Component
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0009360 DNA polymerase III complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Synthesis of DNA pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
G2/M Checkpoints pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Cell Cycle pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
Cell Cycle Checkpoints pathway
KEGG
DNA replication pathway
Nucleotide excision repair pathway
Mismatch repair pathway
INOH
PID BIOCARTA
PID NCI
Fanconi anemia pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5983
UniGene
RefSeq NM_002915 NM_181558
HUGO HGNC:9971
OMIM 600405
CCDS CCDS45025 CCDS9352
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 5983