InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RFC3

Summary

InnateDB Gene

IDBG-23475.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFC3

Gene Name

replication factor C (activator 1) 3, 38kDa

Synonyms

RFC38

Species

Homo sapiens

Ensembl Gene

ENSG00000133119

Encoded Proteins

IDBP-23477

replication factor C (activator 1) 3, 38kDa

IDBP-364423

replication factor C (activator 1) 3, 38kDa

IDBP-811327

replication factor C (activator 1) 3, 38kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:33818049-33966558

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000380071	ENSP00000369411
ENST00000434425	ENSP00000401001
ENST00000616236	ENSP00000484747

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	41 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003689	DNA clamp loader activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0000731	DNA synthesis involved in DNA repair
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0032201	telomere maintenance via semi-conservative replication
GO:0046683	response to organophosphorus