Version 5.4
Homo sapiens Protein: TSC2
Summary
InnateDB Protein IDBP-364647.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSC2
Protein Name tuberous sclerosis 2
Synonyms LAM; PPP1R160; TSC4;
Species Homo sapiens
Ensembl Protein ENSP00000406980
InnateDB Gene IDBG-9819 (TSC2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 115 [view]
Protein-Protein 112 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0032007 negative regulation of TOR signaling
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0033596 TSC1-TSC2 complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5HYF7
UniProt Splice Variant
Entrez Gene 7249
UniGene Hs.90303
RefSeq XP_005255586
HUGO HGNC:12363
OMIM 191092
CCDS
HPRD 01850
IMGT
EMBL AC093513 BX647816
GenPept CAI46010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca