Version 5.4
Homo sapiens Protein: INTS9
Summary
InnateDB Protein IDBP-365642.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS9
Protein Name integrator complex subunit 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000398208
InnateDB Gene IDBG-15350 (INTS9)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Subcellular Localization Nucleus {ECO:0000269PubMed:15684398}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID
InterPro IPR001279 Beta-lactamase-like
IPR022712 Beta-Casp domain
PFAM PF00753
PF10996
PRINTS
PIRSF
SMART SM00849
SM01027
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NV88
PhosphoSite PhosphoSite-Q9NV88
TrEMBL H7BYQ6
UniProt Splice Variant
Entrez Gene 55756
UniGene Hs.613706
RefSeq NP_001138631
HUGO HGNC:25592
OMIM 611352
CCDS CCDS55216
HPRD 07706
IMGT
EMBL AC040975 AC131969 AK001733 AK298468 AK300593 BC025267 BK005674 BK005726 U96629
GenPept AAB67601 AAH25267 BAA91867 BAH12796 BAH13311 DAA05670 DAA05726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca