InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SS18

Summary

InnateDB Protein

IDBP-366034.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SS18

Protein Name

synovial sarcoma translocation, chromosome 18

Synonyms

SSXT; SYT;

Species

Homo sapiens

Ensembl Protein

ENSP00000414516

InnateDB Gene

IDBG-1783 (SS18)

Protein Structure

UniProt Annotation

Function

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. {ECO:0000269PubMed:15919756}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

Tissue Specificity

Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000902	cell morphogenesis
GO:0006351	transcription, DNA-templated
GO:0007010	cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048013	ephrin receptor signaling pathway